Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem

Bioorg Med Chem Lett. 2015 Jan 15;25(2):307-9. doi: 10.1016/j.bmcl.2014.11.045. Epub 2014 Nov 22.

Abstract

Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.

Keywords: Acanthopanax senticosus Harms stem; Enantiomer; Panax ginseng berry pulp; SIRT1; Syringaresinol.

MeSH terms

  • Eleutherococcus / chemistry*
  • Forkhead Box Protein O3
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism
  • Fruit / chemistry*
  • Furans / pharmacology*
  • Human Umbilical Vein Endothelial Cells / drug effects
  • Human Umbilical Vein Endothelial Cells / metabolism
  • Humans
  • Lignans / pharmacology*
  • Panax / chemistry*
  • Plant Extracts / pharmacology*
  • Promoter Regions, Genetic / genetics
  • RNA, Messenger / genetics
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sirtuin 1 / genetics*
  • Sirtuin 1 / metabolism
  • Stereoisomerism
  • Surface Plasmon Resonance

Substances

  • FOXO3 protein, human
  • Forkhead Box Protein O3
  • Forkhead Transcription Factors
  • Furans
  • Lignans
  • Plant Extracts
  • RNA, Messenger
  • syringaresinol
  • SIRT1 protein, human
  • Sirtuin 1